Proton pump inhibitor step-down therapy for GERD: A multi-center study in Japan

Table 1 Population characteristics of study 1 n (%)

Characteristic	ITT population(n = 108)
Gender
Male/female	62 (57.4)/46 (42.6)
Age (yr)
Range	20-88
Median	63
BMI (kg/m2)
≤ 24.9 (normal or below normal)	77 (71.3)
25-29.9 (overweight)	28 (25.9)
≥ 30 (obese)	3 (2.8)
Previous treatment for GERD	38 (35.2)
Duration of GERD symptoms before initial treatment (mo)
< 1	21 (19.4)
1-11	47 (43.5)
≥ 12	40 (37.0)
Tobacco use	24 (22.2)
Alcohol use	44 (40.7)
Helicobacter pylori infection	31 (28.7)
The modified Los Angeles Classification
N/M	20 (18.5)/17 (15.7)
A/B	32 (29.6)/32 (29.6)
C/D	5 (4.6)/2 (1.9)
Atrophic gastritis1	18 (16.7)
Hiatus hernia	57 (52.8)
Ischemic heart disease	9 (8.3)
Diabetes mellitus	11 (10.2)
Bronchial asthma	4 (3.7)

¹Atrophic gastritis was defined as only the O-type of the Kimura-Takemoto classification[20]. BMI: Body mass index; GERD: Gastroesophageal reflux disease; ITT: Intention-to-treat.