Hepatitis B virus infection: A favorable prognostic factor for intrahepatic cholangiocarcinoma after resection

Table 5 Univariate and multivariate analyses of prognostic factors for survival rate of intrahepatic cholangiocarcinoma patients with hepatitis B virus infection

Factor	n	HBV infection		P value		Hazard ratio	95% CI
		1-yr (%)	3-yr (%)	Univariate analysis	Multivariate analyses
r-GT
≤ 64 U/L	38	76.3	52.1
> 64 U/L	49	69.4	34.1	0.223	NA	NA	NA
ALP
≤ 119 U/L	54	85.2	53.2
> 119 U/L	33	60.6	24.2	0.001	0.028	4.800	1.075-3.662
CA19-9
≤ 37 U/mL	43	69.8	41.0
> 37 U/mL	44	75.0	42.5	0.575	NA	NA	NA
Tumor number
single	77	75.3	44.9
multiple	10	50.0	20.0	0.066	0.058	3.599	0.972-5.587
Tumor size
< 5 cm	38	86.8	52.0
≥ 5 cm	49	61.2	33.7	0.049	0.655	0.199	0.436-1.686
Tumor location
Left lobe	28	64.3	42.9
Right lobe	54	79.6	45.5
Both lobes	5	40.0	< 0.01	0.065	0.933	0.007	0.899-1.122
Microscopic satellite lesion
Yes	23	52.2	21.7
No	64	79.7	48.8	0.001	0.001	12.066	1.648-6.014
Capsule formation
Yes	15	60.0	45.7
No	72	75.0	41.0	0.979	NA	NA	NA
Tumor differentiation
Well to moderately	66	71.2	40.3
Poorly	21	76.2	47.1	0.354	NA	NA	NA
Vascular invasion
Yes	22	50.0	17.0
No	65	80.0	50.1	0.007	0.041	4.167	1.030-4.388
Lymphatic metastasis
Yes	12	33.3	< 0.01
No	75	78.7	48.5	< 0.001	0.005	7.887	1.408-6.848
Extrahepatic metastasis
Yes	5	40.0	< 0.01
No	82	74.4	43.1	0.099	0.857	0.032	0.251-3.154

NA: Not applicable; ALP: Alkaline phosphatase; r-GT: R-glutamyltransferase; CA 19-9: Carbohydrate antigen 19-9.