Hepatitis B virus infection: A favorable prognostic factor for intrahepatic cholangiocarcinoma after resection

Table 3 Univariate and multivariate analyses of prognostic factors for disease-free survival rate of intrahepatic cholangiocarcinoma patients included in this study

Factor	n	Survival rate (%)		P value		Hazard ratio	95% CI
		1-yr	3-yr	Univariate analysis	Multivariate analysis
Age (yr)
> 65	20	45	25
≤ 65	112	28.6	19.4	0.243	NA	NA	NA
Sex
Female	43	34.9	20.7
Male	89	29.2	20.1	0.679	NA	NA	NA
HBV infection
Yes	71	39.4	23.5
No	61	21.3	16.4	0.087	0.351	0.869	0.524-1.258
Cirrhosis
Yes	39	25.6	25.6
No	93	33.3	18	0.606	NA	NA	NA
Hepatolithiasis
Yes	7	14.3	< 0.01
No	135	32	21.4	0.041	0.130	2.291	0.807-5.299
Liver schistosomiasis
Yes	6	< 0.01	< 0.01
No	126	32.5	21.2	0.307	NA	NA	NA
r-GT
≤ 64 U/L	59	44.1	28.3
> 64 U/L	73	20.5	13.7	0.005	0.289	1.124	0.797-2.140
ALP
≤ 119 U/L	79	41.8	27.7
> 119 U/L	53	15.1	9.4	0.001	0.589	0.293	0.713-1.813
AFP
≤ 20 μg/L	104	34.6	21.8
> 20 μg/L	28	17.9	14.3	0.212	NA	NA	NA
CA19-9
≤ 37 U/mL	55	40	27.3
> 37 U/mL	77	24.7	15.3	0.048	0.720	0.129	0.707-1.652
Tumor number
single	115	35.7	23.2
multiple	17	< 0.01	< 0.01	< 0.001	0.011	6.515	1.194-3.863
Tumor size
< 5 cm	48	39.6	24.4
≥ 5 cm	84	26.2	17.7	0.135	NA	NA	NA
Tumor location
Left lobe	43	37.2	20.9
Right lobe	81	30.9	21.9
Both lobes	8	< 0.01	< 0.01	0.105	NA	NA	NA
Microscopic satellite lesion
Yes	34	11.8	8.8
No	98	37.8	24.2	0.002	0.017	5.736	1.106-2.745
Histological inflammation
Yes	34	47.3	20.6
No	98	25.5	20.3	0.332	NA	NA	NA
Capsule formation
Yes	14	42.9	21.4
No	118	29.7	20.1	0.683	NA	NA	NA
Tumor differentiation
Well to moderately	98	33.7	21.1
Poorly	34	23.5	17.6	0.647	NA	NA	NA
Vascular invasion
Yes	31	16.1	9.7
No	101	35.6	23.5	0.005	0.025	5.030	1.072-2.812
Lymphatic metastasis
Yes	109	4.3	< 0.01
No	23	36.7	24.5	< 0.001	0.182	1.781	0.834-2.597
Extrahepatic metastasis
Yes	8	< 0.01	< 0.01
No	124	33.1	21.6	0.059	0.609	0.261	0.551-2.764
CK19 staining (n = 130)1
Positive	13	27.4	17.9
Negative	117	61.5	34.6	0.038	0.522	0.410	0.597-2.762

¹Number of available data. AFP: α-fetoprotein; ALP: Alkaline phosphatase; r-GT: R-glutamyltransferase; CA 19-9: Carbohydrate antigen 19-9; CK19: Cytokeratin19; NA: Not available.