Hepatitis B virus infection: A favorable prognostic factor for intrahepatic cholangiocarcinoma after resection

Table 2 Univariate and multivariate analyses of prognostic factors for overall survival rate of intrahepatic cholangiocarcinoma patients included in this study

Factor	n	Survival rate (%)		P value		Hazard ratio	95% CI
		1-yr	3-yr	Univariate analysis	Multivariate analyses
Age (yr)
> 65	28	71.4	33.7
≤ 65	127	58.3	31.8	0.590	NA	NA	NA
Sex
Female	53	64.2	29.4
Male	102	58.8	33.7	0.973	NA	NA	NA
HBV infection
No	68	45.6	20.5
Yes	87	72.4	41.8	0.003	0.044	4.075	0.418-0.987
Cirrhosis
Yes	45	62.6	32.7
No	110	60	31.9	0.964	NA	NA	NA
Hepatolithiasis
Yes	12	16.7	< 0.01
No	143	64.3	34.4	0.001	0.039	4.254	1.040-4.614
Liver schistosomiasis
Yes	7	57.1	14.3
No	148	60.8	33	0.063	0.612	0.257	0.532-2.920
ALT
≤ 42 U/L	113	60.2	32.9
> 42 U/L	42	61.9	29.8	0.956	NA	NA	NA
AST
≤ 37 U/L	102	58.8	32.7
> 37 U/L	53	64.2	30.5	0.949	NA	NA	NA
TBIL
≤ 20 μmol/L	119	60.5	30.7
> 20 μmol/L	36	61.1	37.5	0.355	NA	NA	NA
r-GT
≤ 64 U/L	68	67.6	44.7
> 64 U/L	87	55.2	22.4	0.003	0.102	2.667	0.918-2.547
ALP
≤ 119 U/L	89	71.9	44.5
> 119 U/L	66	45.5	15.8	< 0.001	0.386	0.75	0.758-2.047
AFP
≤ 20 μg/L	125	58.4	32.8
> 20 μg/L	30	70	29.3	0.788	NA	NA	NA
CA19-9
≤ 37 U/mL	66	66.7	41.7
> 37 U/mL	89	56.2	24.7	0.035	0.534	0.388	0.555-1.356
Tumor number
Single	137	63.5	36
Multiple	18	38.9	11.1	0.007	0.188	1.734	0.811-2.913
Tumor size
< 5 cm	58	74.1	42.1
≥ 5 cm	97	52.6	26.1	0.014	0.563	0.335	0.737-1.754
Tumor location
Left lobe	55	52.7	32.2
Right lobe	90	70	35.8
Both lobes	10	20	< 0.01	0.008	0.314	1.015	0.962-1.128
Microscopic satellite lesion
Yes	39	43.6	11.5
No	116	66.4	38.9	< 0.001	0.002	9.418	1.287-3.140
Capsule formation
Yes	17	64.7	45.8
No	138	60.1	30.5	0.251	NA	NA	NA
Tumor differentiation
Well to moderately	118	61.9	33.3
Poorly	37	56.8	29.5	0.785	NA	NA	NA
Vascular invasion
Yes	35	51.4	22.2
No	120	63.3	36.3	0.211	NA	NA	NA
Lymphatic metastasis
Yes	32	28.1	3.1
No	123	69.1	40.8	< 0.001	0.008	7.078	1.193-3.203
Extrahepatic metastasis
Yes	10	20	< 0.01
No	145	63.4	33.7	0.001	0.225	1.474	0.743-3.541
CK19 (n = 153)1
Yes	139	59.7	30.5
No	14	71.4	45.9	0.178	NA	NA	NA

¹Number of tumors. HBV: Hepatitis B virus; TBIL: Total bilirubin; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; AFP: α-fetoprotein; ALP: Alkaline phosphatase; r-GT: R-glutamyltransferase; CA 19-9: Carbohydrate antigen 19-9; CK19: Cytokeratin 19; NA: Not available.