S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer

Table 4 Univariate and multivariate analyses of recurrence and survival (Cox regression)

Variables	Recurrence		Survival
	HR (95% CI)	P value	HR (95% CI)	P value
Univariate analysis
Sex
Male/female	0.872 (0.490-1.549)	0.640	0.857 (0.452-1.624)	0.636
Age (yr)
≤ 60/> 60	1.517 (0.842-2.732)	0.165	1.842 (0.967-3.508)	0.063
Tumor size (cm)
≤ 5/> 5	0.881 (0.165-0.685)	0.687	0.880 (0.444-1.745)	0.715
Tumor location
Colon/rectum	0.823 (0.463-1.464)	0.508	0.920 (0.483-1.752)	0.799
Tumor differentiation
I-II/III-IV	1.234 (0.660-2.305)	0.511	1.171 (0.581-2.361)	0.659
Tumor status
T1-2/T3-4	0.886 (0.484-1.620)	0.693	1.026 (0.517-2.033)	0.942
Lymph node metastasis
N0/N1-2	2.727 (1.510-4.923)	0.001	2.852 (1.463-5.559)	0.002
TNM stage
I-II/III-IV	3.560 (1.940-6.534)	< 0.001	3.393 (1.680-6.850)	< 0.001
S100A4 expression
Negative/positive	3.666 (1.929-6.964)	< 0.001	4.154 (1.963-8.792)	< 0.001
Multivariate analysis
LNM
N0/N1-2	0.205 (0.055-0.769)	0.019	0.193 (0.044-0.857)	0.031
TNM stage
I-II/III-IV	8.915 (2.081-38.189)	0.003	9.057 (1.705-48.108)	0.010
S100A4 expression
Negative/positive	2.454 (1.056-5.705)	0.037	2.888 (1.131-7.379)	0.027

HR: Hazard ratio; CI: Confidence interval.