S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer

Table 3 Relationships of S100A4 expression with clinicopathological factors in colorectal cancer

Clinicopathological factors	n	S100A4 expression		P value1
		Negative	Positive
Sex
Male	59	32	27	0.252
Female	53	23	30
Age (yr)
≤ 60	76	39	37	0.497
> 60	36	16	20
Tumor size (cm)
≤ 5	74	32	42	0.083
> 5	38	23	15
Tumor location
Colon	47	23	24	0.975
Rectum	65	32	33
Tumor differentiation2
I-II	82	43	39	0.244
III-IV	30	12	18
Tumor status2
T1-2	34	18	16	0.592
T3-4	78	37	41
Lymph node metastasis2
N0	59	49	10	< 0.001
N1-2	53	9	44
TNM stage2
I-II	57	46	11	< 0.001
III-IV	55	9	46

¹Statistical analysis was estimated with χ² test, and P < 0.05 was considered statistically significant;

²Grading of differentiation status and TNM classification for colorectal cancer were based on the American Joint Committee on Cancer Cancer Staging Manual (6th edition, 2002). The tumors were classified into two groups: well differentiated (grades I and II) and poorly differentiated (grades III and IV).