S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer

Table 2 Protein expression upregulated and downregulated at least 2.5-fold in lymph node metastasis colorectal cancer compared with non-lymph node metastasis colorectal cancer

Accession No.	Protein name	Protein ratio1	SD	Peptide	Coverage rate (%)
Upregulated
IPI00171494	Isoform 2 of cytoplasmic dynein 2 heavy chain 1	21.8	0	1	2.4
IPI00103253	Isoform 5 of pyrin and hin domain-containing protein 1	8.68	2.85	19	4.9
IPI00298520	Putative uncharacterized protein dkfzp686m09245	7.39	0	1	2.5
IPI00027194	Syntaxin-18	6.30	0	1	3.9
IPI00410639	Isoform 2 of fch and double sh3 domains protein 2	5.25	1.03	5	2.1
IPI00300631	Scaffold attachment factor B1	4.69	0	1	1.51
IPI00009236	Isoform α of caveolin-1	4.42	3.75	2	3.0
IPI00216654	Isoform β of nucleolar phosphoprotein P130	4.35	0	1	1.6
IPI00004273	RNA binding motif protein 25	3.87	0	1	1.5
IPI00239077	Histidine triad nucleotide-binding protein 1	3.73	0.38	5	7.91
IPI00010320	Chromobox protein homolog 1	3.56	1.90	4	1.8
IPI00010274	Isoform 1 of tryptase α-1 precursor	3.52	0.09	2	9.0
IPI00010414	Pdz and lim domain protein 1	3.41	0	1	4.0
IPI00014852	Isoform 1 of phosphoglucomutase-like protein 5	3.24	1.07	4	11.1
IPI00000156	Ligase III, DNA, ATP-dependent isoform β precursor	3.10	0.60	2	2.1
IPI00102821	Isoform 1 of proapoptotic caspase adapter protein precursor	3.09	0.40	2	36.1
IPI00032313	Protein S100-A4	3.04	0.69	2	7.9
IPI00008750	Metallothionein-1H	2.95	0.11	2	27.9
IPI00216153	40S Ribosomal protein S15	2.94	0.57	4	9.0
IPI00654777	Eukaryotic translation initiation factor 3 subunit 5	2.90	0.24	2	5.1
IPI00024933	60S Ribosomal protein L12	2.86	1.02	11	14.4
IPI00025366	Citrate synthase, mitochondrial precursor	2.85	0.47	4	5.9
IPI00007928	Pre-mRNA-processing-splicing factor 8	2.81	0	1	1.3
IPI00024976	Mitochondrial import receptor subunit tom22 homolog	2.78	0	1	8.5
IPI00577039	Annexin A2	2.77	0.32	2	3.6
IPI00062151	Similar to 60s ribosomal protein L15	2.70	0.37	6	6.5
IPI00219757	Glutathione S-transferase P1	2.55	0.37	2	9.1
IPI00396437	Isoform 2 of drebrin-like protein	2.51	0.45	5	2.8
Downregulated
IPI00023673	Galectin-3-binding protein precursor	0.09	0	1	2.2
IPI00011062	Isoform 1 of carbamoyl-phosphatesynthase , mitochondrial precursor	0.10	0	1	1.0
IPI00030279	Isoform 1 of zinc finger ran-binding domain-containing protein 3	0.11	0	1	7.6
IPI00219682	Erythrocyte band 7 integral membrane protein	0.20	0	1	9.8
IPI00433499	Rhomboid, veinlet-like 6 isoform 1	0.20	0	1	2.1
IPI00000230	Tropomyosin 1 α chain isoform 2	0.26	0.06	32	51.8
IPI00029631	Enhancer of rudimentary homolog	0.27	0	1	7.7
IPI00009950	Vesicular integral-membrane protein vip36 precursor	0.30	0	1	3.4
IPI00384603	Isoform 2 of ribonuclease p protein subunit P21	0.30	0.11	13	10.7
IPI00177543	Peptidylglycine α-amidating monooxygenase isoform A	0.31	0.08	2	8.1
IPI00000330	Isoform 1 of uncharacterized protein c9orf80	0.35	0	1	17.6
IPI00298949	Cyclin G-associated kinase	0.35	0	1	1.3
IPI00008964	RAS-related protein rab-1B	0.37	0	1	7.5
IPI00013860	3-Hydroxyisobutyrate dehydrogenase, mitochondrial precursor	0.37	0	1	5.4
IPI00296053	Isoform mitochondrial of fumarate hydratase, mitochondrial precursor	0.39	0.18	1	2.4

¹Protein ratio represents the abundance ratio between lymph node metastasis group and non-lymph node metastasis group. LNM: Lymph node metastasis; CRC: Colorectal cancer.