Increased liver stiffness in alcoholic liver disease: Differentiating fibrosis from steatohepatitis

Table 2 Excluding patients with elevated GOT levels indicating steatohepatitis improves the diagnostic value (AUROC, sensitivity and specificity) of FibroScan for the diagnosis of F3/F4 fibrosis

	Area under the curve (AUROC)	Std. error	Cut-off value (kPa)	Sensitivity	Specificity	Number of includedpatients
F4	0.921	0.03	11.5	1.00	0.77	101
			12.51	0.961	0.801	1011
F4 without GOT > 100 U/L	0.944	0.02	11.5	1.00	0.84	86
			12.51	0.951	0.901	861
F4 without GOT > 50 U/L	0.945	0.03	10.4	1.00	0.87	66
			12.51	0.921	0.911	661
F3/4	0.914	0.03	8.0	0.91	0.75	101
F3/4 without GOT > 100 U/L	0.922	0.03	8.0	0.87	0.87	80
F3/4 without GOT > 50 U/L	0.946	0.03	8.0	1.00	0.84	67

¹Represent commonly used cut-off values (12.5 and 8.0 kPa) for comparison with other studies. Additional cut-off values with 100% sensitivity and different cut-off values for F4 fibrosis are specific to this study.