Methylation of Dickkopf-3 as a prognostic factor in cirrhosis-related hepatocellular carcinoma

Table 3 Cox regression model of progression-free survival

	Univariate analysis			Multivariate analysis1
	RR	95% CI	P	RR	95% CI	P
Tumor size (cm)
> 5.0	3.653	1.085-12.304	0.036	3.345	1.312-8.526	0.011
≤ 5.0	1			1
Portal vein invasion
Positive	2.657	1.023-6.900	0.045	3.188	1.294-7.852	0.012
Negative	1			1
DKK3 methylation
Positive (PMR > 1%)	2.370	0.965-5.823	0.060	2.527	1.063-6.008	0.036
Negative (PMR ≤ 1%)	1			1
AFP (ng/mL)
> 400	1.829	0.759-4.409	0.179			-
≤ 400	1
Age (yr)
> 55	1.552	0.569-4.234	0.391			-
≤ 55	1
Number of tumor
Multiple	0.922	0.280-3.036	0.893			-
Single	1

¹Only the variables with P values less than 0.05 are included in the equation. RR: Relative risk.