Immune phenotype in children with therapy-na&iuml;ve remitted and relapsed Crohn&rsquo;s disease

doi:10.3748/wjg.v16.i47.6001

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 21, 2010; 16(47): 6001-6009
Published online Dec 21, 2010. doi: 10.3748/wjg.v16.i47.6001

Table 3 Prevalence and ratios of cellular members of innate immunity

Cell prevalence in parent population	Control	Therapy-naïve (before conventional therapy)	First remission (with conventional therapy)	Relapse (before IFX therapy)	IFX therapy (before 2nd infusion)	IFX therapy (before 3rd infusion)
NKT in PBMC	1.39 (0.81-2.42)	0.7 (0.11-1.33)^a	0.74 (0.37-1.34)	0.72 (0.45-1.23)	0.73 (0.37-1.20)	0.83 (0.31-2.05)
NK in PBMC	3.17 (1.71-4.76)	1.73 (0.72-3.49)^a	1.98 (1.65-2.97)	1.95 (0.72-4.81)	2.14 (0.66-4.78)	2.45 (1.26-4.85)
DC in PBMC	0.61 (0.10-2.15)	1.05 (0.54-3.32)^a	1.16 (0.58-2.98)^a	1.45 (1.09-3.46)^a	0.86 (0.30-2.80)	0.82 (0.52-2.31)
mDC in DC	46.04 (37.14-52.30)	61.66 (45.37-72.74)^b	45.19 (37.83-56.68)^c	69.01 (40.11-74.79)^a^e	60.01 (48.03-68.50)^a	57.39 (37.19-64.14)^a^g
pDC in DC	27.38 (20.65-33.94)	19.26 (15.08-24.58)^a	21.61 (14.76-32.61)^a	18.33 (16.59-26.42)^a	19.03 (17.26-32.38)	27.39 (19.68-36.70)^g
mDC/pDC ratio	1.85 (0.44-1.46)	3.05 (2.32-6.11)^d	2.35 (1.80-9.10)^b^c	3.5 (1.74-7.79)^d	3.04 (2.03-4.65)^d	2.20 (1.66-5.54)^b^g
TLR-2 in DC	8.8 (4.14-17.35)	55.08 (37.27-57.94)^d	17.32 (6.32-32.54)^c	38.7 (19.31-54.59)^b^e	25.89 (5.69-60.43)	16.70 (2.29-42.61)^g
TLR-4 in DC	2.24 (0.90-2.78)	14.36 (6.26-19.20)^b	2.73 (1.35-7.21)^f	10.11 (2.29-19.55)^a^e	5.31 (2.81-13.42)	3.32 (0.10-6.05)^g
Monocyte in PBMC	2.01 (1.38-3.82)	8.57 (3.82-16.72)^b	5.96 (2.49-21.22)^a^c	7.3 (2.65-15.44)^a	5.58 (2.78-17.52)^a	5.31 (3.54-6.94)^a
TLR-2 in monocyte	16.44 (10.31-19.69)	29.65 (17.83-39.77)^a	20.92 (7.87-29.15)^c	20.63 (7.05-29.01)	19.89 (13.13-29.32)	18.52 (10.29-28.96)
TLR-4 in monocyte	7.17 (0.45-14.73)	14.59 (3.01-35.23)^a	4.43 (1.82-8.31)^c	10.39 (2.10-26.54)	8.26 (2.71-17.56)	6.30 (2.48-18.94)

^aP < 0.05,

^bP < 0.01,

^dP < 0.001 vs control;

^cP < 0.05,

^fP < 0.01 vs therapy-naïve;

^eP < 0.05 vs first remission;

^gP < 0.05 vs relapse. Data are expressed as median (interquartile range). IFX: Infliximab; PBMC: Peripheral blood mononuclear cell; NK: Natural killer, CD3^-CD161⁺; NKT: Natural killer T, CD3⁺6b11⁺; DC: Dendritic cell, Lin1-HLA-DR⁺; mDC: Myeloid dendritic cell, CD11c⁺; pDC: Plasmocytoid dendritic cell, CD123⁺; Monocyte (CD14⁺); TLR: Toll-like receptor.

Citation: Cseh A, Vasarhelyi B, Molnar K, Szalay B, Svec P, Treszl A, Dezsofi A, Lakatos PL, Arato A, Tulassay T, Veres G. Immune phenotype in children with therapy-naïve remitted and relapsed Crohn’s disease. World J Gastroenterol 2010; 16(47): 6001-6009
URL: https://www.wjgnet.com/1007-9327/full/v16/i47/6001.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i47.6001