PPIs are not associated with a lower incidence of portal-hypertension-related bleeding in cirrhosis

Table 2 Univariate and multivariate analyses of risk factors associated with portal-hypertension related bleeding in cirrhotic patients

	B Coefficient	Standarderror	Wald χ2	OR (95% CI)	P value
Univariate
Age ≥ 60	-	-	-	1.1 (0.37-3.5)	1
Sex, male	-	-	-	1.7 (0.5-5.2)	0.39
CPT C	-	-	-	1.6 (0.40-6.6)	0.36
GERD	-	-	-	0.53 (0.15-1.8)	0.31
MELD > 15	-	-	-	1.2 (0.35-4.4)	0.47
PPI use	-	-	-	0.83 (0.5-1.3)	0.51
LEV	-	-	-	12 (3-123)	< 0.001
Red signs	-	-	-	10 (2-58)	< 0.001
NSAID	-	-	-	0.86	0.55
Multivariate
LEV	23.7	15.1	0	10 (4-110)	< 0.001
Red signs	22.0	14.2	0	9 (4-102)	< 0.001

CPT C: Child-pugh-turcotte class C; GERD: Gastroesophageal reflux disease; MELD: Model for end stage liver disease; PPI: Proton pump inhibitor; LEV: Large Esophageal varices; NSAID: Non-steroidal anti-inflammatory drugs; OR: Odds ratio; CI: Confidence interval.