Chronic stress sensitizes rats to pancreatitis induced by cerulein: Role of TNF-α

Figure 5 Chronic stress plus submaximal cerulein stimulation induces mild to moderate pancreatitis. Rats exposed to sessions of restraint (4 h every day for 21 d), Stress (+) groups, and rats in the control, Stress (-) groups, received daily intraperitoneal (ip) injections of either tumor necrosis factor-α (TNF-α)-neutralizing antibody (50 μg/kg) or control IgG. Rats were then treated with six hourly ip injections of either saline or cerulein (Cer, 0.2 μg/kg). Representative histology images of pancreatic tissue. HE, original magnification, 40 ×.