Tumor budding predicts response to anti-EGFR therapies in metastatic colorectal cancer patients

Table 2 Predictive ability of each feature for partial response

Feature	Total No. of patients	No. of correctly predicted PR	No. of correctly predicted PD + SD	No. of PD + SD predicted as PR	No. of PR predicted as PD + SD	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Accuracy (%)	P-value
Budding ( ≤ 15 cells)	43	13	11	19	0	100	40.6	37	100	68.3	0.011
EGFR (no AMP/CNG)	38	10	4	24	0	100	29.4	14	100	57.1	0.556
K-RAS (wild-type)	43	13	11	19	0	100	40.6	37	100	68.3	0.011
B-RAF (wild-type)	43	13	5	25	0	100	34.2	17	100	58.3	0.301
PIK3CA (wild-type)	43	13	2	28	0	100	31.7	7	100	53.3	1.0
PTEN (positive)	43	12	11	19	1	91.7	38.7	37	92.3	64.5	0.07

PD: Progressive disease; SD: Stable disease; PR: Partial response; EGFR: Epidermal growth factor receptor; PPV: Positive predictive value; NPV: Negative predictive value; AMP/CNG: Amplification or copy number gain.