A new index for non-invasive assessment of liver fibrosis

doi:10.3748/wjg.v16.i38.4809

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 14, 2010; 16(38): 4809-4816
Published online Oct 14, 2010. doi: 10.3748/wjg.v16.i38.4809

Table 4 Assessment of liver fibrosis stages classification by liver fibrosis indices

	AUCs (95% CI)	Optimal cutoff value	Sensitivity (%)	Specificity (%)	Accuracy (%)	Positive predictive value (%)	Negative predictive value (%)	Positive likelihood ratio
F ≥ 1 (F0 vs F1-2-3-4)
Fibro-Stiffness index	0.82 (0.715-0.928)	11.07	77.5	78.6	77.6	97.5	24.4	3.62
Fibro-Stiffness index and AST	Non	11.07 and 51 (IU/L)	85.4	78.6	84.8	97.7	33.3	3.99
Liver stiffness	0.77 (0.666-0.867)	6.6 (kPa)	64.2	85.7	66.1	97.8	18.2	4.49
APRI	0.81 (0.680-0.934)	0.44	88.1	64.3	86.1	96.4	33.3	2.47
Forns index	0.77 (0.640-0.908)	4.72	82.1	71.4	81.2	96.9	27.0	2.87
FibroIndex	0.85 (0.757-0.932)	1.19	82.1	75.0	81.5	97.3	27.3	3.28
F ≥ 2 (F0-1 vs F2-3-4)
Fibro-Stiffness index	0.90 (0.847-0.943	10.12	78.8	89.4	83.0	91.8	73.8	7.43
Liver stiffness	0.88 (0.826-0.929)	7.1 (kPa)	80.8	80.3	80.6	86.0	73.6	4.10
APRI	0.78 (0.714-0.851)	1.06	64.6	84.8	72.7	86.5	61.5	4.27
Forns index	0.82 (0.757-0.890)	6.22	76.8	83.3	79.4	87.4	70.5	4.61
FibroIndex	0.82 (0.754-0.888)	17.00	74.2	80.7	76.7	85.7	66.7	3.84
F ≥ 3 (F0-2 vs F3-4)
Fibro-Stiffness index	0.90 (0.851-0.953)	9.87	93.0	79.6	84.2	70.7	96.7	4.56
Liver stiffness	0.90 (0.856-0.952)	9.6 (kPa)	87.7	82.4	84.2	72.5	92.7	4.98
APRI	0.84 (0.767-0.904)	1.13	80.7	80.6	80.6	68.7	88.8	4.15
Forns index	0.80 (0.732-0.874)	6.36	82.5	70.4	74.5	59.5	88.4	2.78
FibroIndex	0.85 (0.749-0.901)	1.85	73.6	80.6	81.4	68.4	84.3	3.80
F = 4 (F0-1-2-3 vs F4)
Fibro-Stiffness index	0.92 (0.871-0.965)	8.51	91.7	83.7	84.8	48.9	98.3	5.62
Fibro-Stiffness index and HA	Non	8.51 and 68 (ng/mL)	91.3	87.9	88.4	55.3	98.4	7.26
Liver stiffness	0.90 (0.844-0.957)	11.6 (kPa)	91.7	78.0	80.0	41.5	98.2	4.17
APRI	0.84 (0.759-0.915)	1.30	91.7	74.5	77.0	37.9	98.1	3.59
Forns index	0.87 (0.816-0.923)	7.07	95.8	75.9	78.8	40.4	99.1	3.97
FibroIndex	0.89 (0.830-0.943)	1.90	91.3	78.0	80.1	43.8	98.0	4.16

AUCs: Area under the receiver operating characteristics; CI: Confidence interval; HA: Hyaluronic acid; AST: Aspartate aminotransferase; APRI: Aminotransferase-to-platelet ratio index.

Citation: Ichino N, Osakabe K, Nishikawa T, Sugiyama H, Kato M, Kitahara S, Hashimoto S, Kawabe N, Harata M, Nitta Y, Murao M, Nakano T, Arima Y, Shimazaki H, Suzuki K, Yoshioka K. A new index for non-invasive assessment of liver fibrosis. World J Gastroenterol 2010; 16(38): 4809-4816
URL: https://www.wjgnet.com/1007-9327/full/v16/i38/4809.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i38.4809