Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer

Table 3 Distribution of SOD1 G7958A and SOD2 Val16Ala polymorphisms

Variable	HC (%)	GPL (%)	GC (%)	1P	GC vs GPL	GC vs HC
	n = 147	n = 145	n = 140		2OR (95% CI)/P	2OR(95% CI)/P
SOD1
GG	78 (53.1)	47 (32.4)	39 (27.9)		1.00	1.00
AG	57 (38.8)	72 (49.7)	72 (51.4)		1.16 (0.67-2.02)/0.593	2.60 (1.54-4.39)/< 0.001
AA	12 (8.2)	26 (17.9)	29 (20.7)	< 0.0013	1.32 (0.66-2.62)/0.429	4.94 (2.26-10.80)/< 0.001
A/-	69 (46.9)	98 (67.6)	101 (72.1)	< 0.0014	1.21 (0.72-2.03)/0.483	3.01 (1.83-4.95)/< 0.001
SOD2
Val/Val	119 (81.0)	112 (77.2)	85 (60.7)		1.00	1.00
Ala/Val	27 (18.4)	31 (21.4)	48 (34.3)		2.04 (1.19-3.49)/0.009	2.57 (1.48-4.48)/0.001
Ala/Ala	1 (0.7)	2 (1.4)	7 (5.0)	0.0015	4.50 (0.91-22.29)/0.065	10.68 (1.26-90.79)/0.030
Ala/-	28 (19.0)	33 (22.8)	55 (39.3)	< 0.0016	2.19 (1.30-3.68)/0.003	2.85 (1.66-4.89)/< 0.001

¹P values were calculated by χ² test; ²Adjusted for age, sex, OR, 95% CI, P values were calculated by logistic regression;

³GG vs AG vs AA;

⁴GG vs A/-;

⁵Val/Val vs Ala/Val vs Ala/Ala;

⁶Val/Val vs Ala/-. A/-: AA + AG; Ala/-: Ala/Val + Ala/Ala. HC: Healthy control; GPL: Gastric precancerous lesion; GC: Gastric cancer.