Association of symptoms with gastrointestinal microbiota in irritable bowel syndrome

Figure 1 Principal component analysis of bacterial data and patient symptom scores. A: Dimension 1 explains 20.4% of the observed variation among test subjects when bacterial data and symptom groups are studied. The four symptom groups have correlations with Dimension 1 of 0.77-0.63, all with P < 0.001, and Ruminococcus torques 94% has a correlation of 0.58, with P < 0.001. Coprococcus eutactus 97%, Bifidobacterium spp., Veillonella spp. and Desulfovibrio desulfuricans-group also present significant, albeit smaller, negative correlations with Dimension 1; B: When the bowel symptom sum is studied question-wise, individual symptoms (except for soiling) as well as Ruminococcus torques 94% show a significant correlation of 0.57-0.75, with P < 0.001, with Dimension 1. Negative associations are observed for Collinsella aerofaciens-like, Coprococcus eutactus 97%, Veillonella spp., Lactobacillus spp. and Bifidobacterium spp.