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©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Sep 21, 2010; 16(35): 4400-4409
Published online Sep 21, 2010. doi: 10.3748/wjg.v16.i35.4400
Published online Sep 21, 2010. doi: 10.3748/wjg.v16.i35.4400
Table 1 Characteristics of 938 chronic hepatitis C genotype 1 patients treated with a combination of pegylated interferon plus ribavirin according to age (mean ± SD)
| Group A (age < 65 yr) (n = 685) | Group B (age≥65 yr) (n = 253) | P-value | |
| Age (yr) | 53.1 ± 8.9 | 68.6 ± 3.1 | < 0.001 |
| Male/female | 374/311 | 122/131 | 0.090 |
| Body mass index (kg/m2) | 23.7 ± 3.3 | 22.8 ± 2.7 | < 0.001 |
| Prior IFN monotherapy, n (%) | 163 (23.8) | 76 (30.0) | 0.052 |
| Prior combined IFN plus RBV treatment, n (%) | 51 (7.4) | 20 (7.9) | < 0.001 |
| Alanine aminotransferase (IU/L) | 80.2 ± 62.0 | 67.9 ± 46.6 | 0.004 |
| γ-glutamyltranspeptidase (IU/L) | 60.2 ± 56.6 | 57.1 ± 49.2 | 0.708 |
| Albumin (g/dL) | 4.1 ± 0.4 | 4.0 ± 0.4 | < 0.001 |
| White blood cell count (/mm3) | 5200.0 ± 1476.7 | 4756.3 ± 1458.9 | < 0.001 |
| Hemoglobin (g/dL) | 14.1 ± 1.4 | 13. 5 ± 1.4 | < 0.001 |
| Platelet count (109/L) | 16.6 ± 5.3 | 15.0 ± 5.2 | < 0.001 |
| Creatinine (mg/dL) | 0.7 ± 0.6 | 0.8 ± 1.4 | 0.107 |
| Creatinine clearance (mL/min) | 105.5 ± 28.7 | 75.8 ± 17.5 | < 0.001 |
| Serum HCV-RNA level (kIU/mL) | 1776.1 ± 1500.0 | 1986.9 ± 1604.5 | 0.125 |
| Histological fibrosis | 0.008 | ||
| F0/F1/F2/F3/F4 | 36/155/121/61/30 | 9/46/49/31/17 |
- Citation: Kainuma M, Furusyo N, Kajiwara E, Takahashi K, Nomura H, Tanabe Y, Satoh T, Maruyama T, Nakamuta M, Kotoh K, Azuma K, Shimono J, Shimoda S, Hayashi J, Group TKULDS. Pegylated interferon α-2b plus ribavirin for older patients with chronic hepatitis C. World J Gastroenterol 2010; 16(35): 4400-4409
- URL: https://www.wjgnet.com/1007-9327/full/v16/i35/4400.htm
- DOI: https://dx.doi.org/10.3748/wjg.v16.i35.4400