Liver transplantation for alcoholic liver disease

Table 4 Outcome of post-orthotopic liver transplantation in patients with alcoholic liver disease, combined alcoholic liver disease with hepatitis C virus and hepatitis C virus alone n (%)

Study	ALD	ALD + HCV	HCV	Others
Burra et al[76]	n = 9880	n = 1119	n = 6672
Patient survival 1-yr, 3-yr, 5-yr, 10-yr	84%, 78%, 73%, 58%	84%, 75%, 65%, 52%	81%, 72%, 67%,54%
Aguilera et al[77]	n = 107	n = 60	n = 170
HCC	19 (18)	21 (35)	75 (44)
Graft loss	35 (33)	25 (42)	95 (56)
Severe recurrent HCV disease		22/49 (45)	54/122 (45)
Retransplant	4 (4)	8 (13)	7 (4)
De-novo tumors	14/107 (13)	2/67 (3)	10/67 (6)
Rejection	17/100 (17)	9/60 (15)	32/169 (19)
Patient survival 1-yr, 5-yr, 7-yr	90%, 76%, 67%	86%, 73%, 63%	72%, 49%, 43%
Graft survival 1-yr, 5-yr, 7-yr	89%, 76%, 67%	83%, 63%, 56%	71%, 48%, 43%
Mortality	29 (27)	21 (35)	95 (56)
Cause of death
Recurrent disease	3 (3)	9 (15)	44 (26)
Sepsis	7 (6.5)	7 (12)	26 (15)
De-novo tumors	9 (8)	2 (3.5)	6 (3.5)
Neuberger et al[4]
HCC (%)	11	26	28
Yamauchi et al[78] Yamanaka et al[79]
Risk of HCC (at 10-yr)	15%-20%	50%-80%
Khan et al[80]	n = 14	n = 24	n = 40	n = 42
HCV RNA (Meq/mL)		2.3 ± 1.7	2.7 ± 2.9	2.3 ± 2.6
Necroinflammation	1.8 ± 0.7	3.1 ± 1.1	3.4 ± 1.6	2.9 ± 1.3
Fibrosis	2.9 ± 1.0	3.6 ± 0.7	2.9 ± 0.9	3.4 ± 1.0
Cirrhosis	5 (8.4)	16 (27.2)	10 (16.9)	28 (47.5)
HCC	5 (9)	14 (25.5)	10 (18.2)	26 (47.3)
Size of HCC	1.9 ± 0.8	2.5 ± 0.8	2.5 ± 1.0	2.4 ± 0.9
Donato et al[81]
Relative risk for HCC	4.6	64.7	23.2

HCV: Hepatitis C virus; HCC: Hepatocellular carcinoma; ALD: Alcoholic liver disease.