Association of NOD1 (CARD4) insertion/deletion polymorphism with susceptibility to IBD: A meta-analysis

Table 2 Meta-analysis of association between NOD1/CARD4 insertion/deletion polymorphism and inflammatory bowel disease

Polymorphism	Disease	Sample size		n	Test of association				Test of heterogeneity
		Case	Control		OR (95%CI)	Z	P value	Model	χ2	P value	I2(%)
GG vs T	Overall	12 878	9596	8	0.98 (0.90-1.07)	0.39	0.70	R	12.60	0.08	44.4
	CD	7782	9596	8	0.96 (0.86-1.07)	0.78	0.43	R	14.49	0.04	51.7
	UC	4900	7448	6	1.01 (0.92-1.09)	0.14	0.89	F	5.12	0.40	2.3
	IBD onset < 40	1486	4752	4	0.68 (0.50-0.93)	2.38	0.02	R	8.30	0.04	63.9
GG/T + GG/GG vs T/T	Overall	6439	4798	8	1.00 (0.98-1.08)	0.01	0.99	F	10.69	0.15	34.5
	CD	3891	4798	8	0.97 (0.86-1.10)	0.42	0.67	R	12.36	0.09	43.4
	UC	2450	3724	6	1.00 (0.90-1.11)	0.06	0.95	F	4.64	0.46	0.0
	IBD onset < 40	743	2376	4	0.71 (0.59-0.85)	3.65	0.0003	F	4.83	0.18	37.8
GG/GG vs T/T + GG/T	Overall	6439	4798	8	0.95 (0.81-1.11)	0.62	0.53	F	12.02	0.10	41.8
	CD	3891	4798	8	0.91 (0.76-1.09)	0.99	0.32	F	11.74	0.11	40.4
	UC	2450	3724	6	1.03 (0.83-1.27)	0.23	0.81	F	4.89	0.43	0.0
	IBD onset < 40	743	2376	4	0.61 (0.28-1.35)	1.22	0.22	R	7.98	0.05	62.3
GG/GG vs T/T	Overall	4033	3020	8	0.93 (0.74-1.17)	0.63	0.53	R	12.59	0.08	44.4
	CD	2442	3020	8	0.88 (0.68-1.14)	0.96	0.34	R	12.96	0.07	46.0
	UC	1623	2312	6	0.97 (0.78-1.20)	0.32	0.75	F	3.04	0.69	0.0
	IBD onset < 40	500	1435	4	0.52 (0.22-1.21)	1.52	0.13	R	8.84	0.03	66.0
GG/T vs T/T	Overall	2816	2098	8	0.95 (0.80-1.12)	0.64	0.53	F	10.85	0.15	35.5
	CD	1685	2098	8	0.92 (0.76-1.11)	0.92	0.36	F	9.94	0.19	29.6
	UC	1093	1648	6	1.03 (0.83-1.28)	0.27	0.79	F	4.67	0.46	0.0
	IBD onset < 40	290	1112	4	0.94 (0.64-1.37)	0.33	0.74	F	5.95	0.11	49.6

R: Random effect model; F: Fixed effect model; IBD: Inflammatory bowel disease; CD: Crohn’s disease; UC: Ulcerative colitis.