Endoscopic ultrasound in chronic pancreatitis: Where are we now?

Table 1 Diagnostic value of endoscopic ultrasonography in chronic pancreatitis

Author	No. of pts	No. of EUS criteria	Threshold for CP diagnosis	Comparison	Sn	Sp	PPV	NPV	Acc
Wiersema et al[4]	69	11	> 3 = dg	EUS vs ERCP	100	79
				EUS vs ERCP + secretin test	70	33
				EUS vs ERCP + history	90	66
Catalano et al[2]	80	11	1-2 mild	EUS vs secretin test	84	78
			3-5 moderate	EUS vs ERCP	86.1	95.4
			> 5 severe	EUS vs ERCP + secretin test	84.2	97.6
Sahai et al[8]	126	9	> 2 for any CP	EUS vs ERCP			> 85	< 85
			< 3 = fibrosis
			> 6 = severe				> 85
Conwell et al[14]	56	9	4-5 = equivocal	EUS vs ePFT	36	94	93	41
			> 6 = definite		26	100	100	39
Stevens et al[13]	83	9	3-5 = dg	EUS vs ERCP	68	79	83	62
			6-9 = severe
Stevens et al[10]	100	9	> 4	Radial EUS vs ePFT	68	95			84
				Linear EUS vs ePFT	44	95			74
Stevens et al[12]	50	9	> 4	EUS vs secretin ePFT	71	92
				EUS vs CCK ePFT	63	85
Zimmermann et al[23]	21	9	> 4	EUS vs histology (surgery)	78	73
Varadarajulu et al[24]	21	9	> 4	EUS vs histology1 (surgery)	90	85.7			88.1
Chong et al[25]	71	9	> 3 = dg	EUS vs histology1 (surgery)	83.3	80
			> 4 = severe fibrosis
Bhutani et al[22]	11	9	> 3	EUS vs histology (autopsy)

¹Non-calcific chronic pancreatitis. ePFT: Endoscopic pancreatic function test; EUS: Endoscopic ultrasonography; ERCP: Endoscopic retrograde cholangiopancreatography; Sn: Sensitivity; Sp: Specificity; Acc: Accuracy; CCK: Cholecystokinin; PPV: Positive predictive value; NPV: Negative predictive value.