Non-alcoholic steatohepatitis and influence of age and gender on histopathologic findings

Table 1 Histopathologic grading (Brunt)[18] of different finding in liver biopsies of non-alcoholic steatohepatitis patients

Finding	Grading
Hepatosteatosis
Grade I	< 33% of hepatocytes affected
Grade II	33%-66% of hepatocytes affected
Grade III	> 66% of hepatocytes affected
Fibrosis
No fibrosis	No fibrosis
Grade I	Zone 3 perisinusoidal pericellular fibrosis, focally or extensively present
Grade II	Zone 3 perisinusoidal pericellular fibrosis, with focal or extensive periportal fibrosis
Grade III	Zone 3 perisinusoidal pericellular fibrosis and portal fibrosis with extensive or focal bridging fibrosis
Cirrhosis	Cirrhosis
Hepatocyte ballooning
No ballooning	No ballooning
Grade I	Sometimes, zone 3
Grade II	Evident, zone 3
Grade III	Symptomatic, more dominant in zone 3
Lobar inflamation
No change	No change
Grade I	Diffuse neutrophils, monocytes at 1 or 2 points in a 20 × microscopic field
Grade II	PMN with ballooning hepatocytes, chronic inflammation at 2 to 4 points in a 20 × microscopic field
Portal inflamation
No change	No change
Grade I	Mild, some portal areas
Grade II	Mild to moderate, most portal areas
Grade III	Moderate to severe, most portal areas

PMN: Polymorphonuclear leukocyte.