Review
Copyright ©2010 Baishideng Publishing Group Co.
World J Gastroenterol. Aug 28, 2010; 16(32): 4019-4030
Published online Aug 28, 2010. doi: 10.3748/wjg.v16.i32.4019
Table 1 General characteristics of most commonly used vectors
SystemSize of insert (kb)Infect non-dividing cellGenomic integrationDuration of expressionImmune response
Adenovirus
1st generation5YesNo3-4 wkHigh
2nd generation8YesNoLonger with Immuno-supressionHigh
Gutless35YesNoLess
Adeno-associated virus< 4.8YesYes and episomalLong-termLow
Herpes simplex virus 135YesNoLongHigh
Retrovirus ≤ 8NoYes, randomLong-termLow
Lentivirus ≤ 8YesYes, into active genesLong-termLow
Baculovirus> 20YesNoTransientLow
Plasmid-nakedLargeYesNoShortLow
Plasmid-polymerLargeYesNoShortLow
Plasmid-lipid (liposomes)LargeYesNoShortLow