Neoadjuvant treatment of esophageal cancer

Table 2 Randomized controlled trials of neoadjuvant radiotherapy vs surgery alone for esophageal cancer

Studies	Histology	Treatment	n	MS (mo)	5-yr OS (%)	P	RT dose (Gy)
Launois et al[48], 1981	SCC	NART	77	10	10	NS	40
		Surgery	57	12	12
Gignoux et al[49], 1987	SCC	NART	106	11	11	NS	33
		Surgery	102	11	10
Arnott et al[50], 1992	AC/SCC	NART	90	8	9	NS	20
		Surgery	86	8	17
Nygaard et al[51], 1992	SCC	NART	481		213	NS	35
		Surgery	412		93
Wang et al[52], 1989	SCC	NART	104		35	NS	40
		Surgery	102		30

¹Group 3: NART;

²Group 1: Surgery alone;

³3-year OS. MS: Median survival; RT: Radiotherapy; SCC: Squamous cell carcinoma; AC: Adenocarcinoma; NART: Neoadjuvant radiotherapy; NS: Not significant; OS: Overall survival.