Gentiana manshurica Kitagawa prevents acetaminophen-induced acute hepatic injury in mice via inhibiting JNK/ERK MAPK pathway

Figure 4 Liver histopathology and transferase-mediated dUTP nick end-labeling (TUNEL) assay. APAP was given intraperitoneally with a single dose of 300 mg/kg. GM was given orally with a single dose of 200 mg/kg. A and E: Normal group; B and F: APAP group; C and G: APAP plus GM 200 mg/kg; D and H: Only GM 200 mg/kg. Upper panels stand for HE staining and the lower panels for TUNEL assay. The regions by black arrows in the upper figures indicate the hepatocyte necrosis or hepatocyte degeneration; the regions by red arrows in the lower figures indicate the TUNEL-positive apoptotic cells (× 100 magnification).