Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Aug 7, 2010; 16(29): 3697-3703
Published online Aug 7, 2010. doi: 10.3748/wjg.v16.i29.3697

Table 3 Immunohistochemical study of the global group¹n (%)

	Normal expression	Lack of expression
Mismatch repair system proteins
Mlh1	24 (86)	4 (14)
Msh2	24 (86)	4 (14)
Msh6	23 (88)	3 (12)
Apoptosis
Bcl-2	7 (25)	21 (75)
Cell adhesion
β-catenin
Membrane	24 (86)	4 (14)
Nucleus	10 (36)	18 (64)
E-cadherin	19 (73)	7 (27)
Cell cycle markers
Chk2	13 (54)	11 (46)
Cyclin A	13 (46)	15 (54)
Cyclin D1	12 (43)	16 (57)
Cyclin D3	12 (43)	16 (57)
Cyclin E	8 (30)	19 (70)
p16	13 (48)	14 (52)
p21	14 (56)	11 (44)
p27	12 (52)	11 (48)
RB-P	13 (48)	14 (52)
Skp2	12 (46)	14 (54)
Cdk2	13 (48)	14 (52)
Proliferation
p53	15 (54)	13 (46)
Ki-67	17 (63)	6 (37)
Others
CK20	10 (59)	7 (41)
RAD50	10 (63)	6 (37)
SMAD4	13 (54)	11 (46)

¹Not all tumors could be studied by immunohistochemical.

Citation: Perea J, Alvaro E, Rodríguez Y, Gravalos C, Sánchez-Tomé E, Rivera B, Colina F, Carbonell P, González-Sarmiento R, Hidalgo M, Urioste M. Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics. World J Gastroenterol 2010; 16(29): 3697-3703
URL: https://www.wjgnet.com/1007-9327/full/v16/i29/3697.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i29.3697

Perea J, Alvaro E, Rodríguez Y, Gravalos C, Sánchez-Tomé E, Rivera B, Colina F, Carbonell P, González-Sarmiento R, Hidalgo M, Urioste M. Approach to early-onset colorectal cancer: Clinicopathological, familial, molecular and immunohistochemical characteristics. World J Gastroenterol 2010; 16(29): 3697-3703 [PMID: 20677343 DOI: 10.3748/wjg.v16.i29.3697]

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