Precise prediction model and simplified scoring system for sustained combined response to interferon-α

Table 5 Optimal cut-off values by maximizing the Youden index and their accuracies for the sustained combined response score derived from whole study population and validated with leave-one-out cross-validation

	Value	95% CI
Total study population
Optimal cut-off	169
Sensitivity (%)	78.79	71.93-84.33
Specificity (%)	80.58	75.81-84.61
Positive predictive value (%)	68.42	61.50-74.61
Negative predictive value (%)	87.68	83.34-91.00
Positive likelihood ratio	4.06	3.19-5.16
Negative likelihood ratio	0.26	0.20-0.36
Odds ratio	15.25	9.65-24.68
Accuracy (%)	79.96	76.12-83.31
Youden index	0.594	0.5913-0.5961
AUC	0.797	0.773-0.812
Leave-one-out cross-validation
Optimal cut-off	169
Sensitivity (%)	78.18	71.28-83.80
Specificity (%)	79.94	75.11-84.02
Positive predictive value (%)	67.54	60.61-73.78
Negative predictive value (%)	87.28	82.89-90.67
Positive likelihood ratio	3.90	3.08-4.94
Negative likelihood ratio	0.27	0.20-0.37
Odds ratio	14.13	8.98-22.73
Accuracy (%)	79.32	75.45-82.73
Youden index	0.581	0.5787-0.5836
AUC	0.79	0.779-0.807

AUC: Area under the curve.