Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?

Table 1 Demographic, clinical, and histological characteristics of subjects categorized by their pretest probability of having CD and from newly diagnosed CD patients from each subgroup

Characteristic	High pretest	Low pretest	P value
No. of subjects enrolled (F/M)	161 (131/30)	518 (351/167)
Mean age (range), yr	40 (16-80)	46 (16-87)
No. of CD patients (%)	63 (39.1)	17 (3.3)
Body mass index
mean ± SE (kg/m2)	20.6 ± 3.9	25.2 ± 5.0	< 0.0001
Histological characterization of duodenal biopsy samples (Marsh’s modified)[25]
Type 0 (No. of patients)	97	495
Type I	0	5
Type II	1	1
Type IIIa	4	6
Type IIIb	12	4
Type IIIc	47	7	< 0.0001
Newly diagnosed CD patients
No. of patients	63	17
Mean age (range), yr	37 (24-74)	37 (19-72)
Body mass index
mean ± SE (kg/m2)	19.6 ± 3.1	23.6 ± 5.0	< 0.0001
Clinical categorization at diagnosis
No. of patients (%)
Classical CD	52	1	< 0.0001
Atypical CD	11	10	< 0.0010
Silent CD	0	6	< 0.0001

CD: Celiac disease.