Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis

Table 5 Estimated VDR haplotype frequencies [FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms] in patients with liver cirrhosis of viral and alcoholic origin according to the presence of HCC

Alcoholic cirrhosis (n = 103)						Viral cirrhosis (n = 137)
HCC present (n = 30)			HCC absent (n = 73)			HCC present (n = 50)			HCC absent (n = 87)
Haplotypes	n	Frequencies	Haplotypes	n	Frequencies	Haplotypes	n	Frequencies	Haplotypes	n	Frequencies
C-A-T-C	9	0.150	C-A-T-C	50	0.343	C-A-T-C	40	0.40	C-A-T-C	64	0.368
T-G-G-T	16	0.267	T-G-G-T	30	0.205	T-G-G-T	15	0.15	T-G-G-T	38	0.218
C-G-G-T	18	0.300	C-G-G-T	32	0.219	C-G-G-T	19	0.19	C-G-G-T	27	0.155
C-G-T-T	14	0.233	C-G-T-T	15	0.103	C-G-T-T	5	0.05	C-G-T-T	17	0.098
T-A-T-C	1	0.017	T-A-T-C	10	0.068	T-A-T-C	7	0.07	T-A-T-C	15	0.086
T-G-T-T	2	0.033	T-G-T-T	4	0.027	T-G-T-T	11	0.11	T-G-T-T	11	0.063
			C-A-T-T	1	0.007	C-A-T-T	2	0.02	C-G-T-C	1	0.006
			C-G-T-C	2	0.014	C-G-T-C	1	0.01	T-A-T-T	1	0.006
			C-G-G-C	2	0.014

The statistical analysis was performed by means of the exact test for sample differentiation based on haplotype frequencies. Non-viral liver cirrhosis with HCC vs (a) viral liver cirrhosis without HCC, P < 0.01, (b) viral liver cirrhosis with HCC, P < 0.05.