Vitamin D receptor gene polymorphisms and hepatocellular carcinoma in alcoholic cirrhosis

Table 3 Estimated VDR haplotype frequencies [FokI C>T (F/f), BsmI A>G (B/b), ApaI T>G (A/a) and TaqI T>C (T/t) polymorphisms] in control subjects and in patients with liver cirrhosis of viral and alcoholic origin

Control subjects (n = 236)			Alcoholic cirrhosis (n = 103)			Viral cirrhosis (n = 137)
Haplotypes	n	Frequencies	Haplotypes	n	Frequencies	Haplotypes	n	Frequencies
C-A-T-C	139	0.295	C-A-T-C	59	0.286	C-A-T-C	103	0.376
T-G-G-T	102	0.216	T-G-G-T	46	0.223	T-G-G-T	56	0.204
C-G-G-T	99	0.210	C-G-G-T	50	0.243	C-G-G-T	43	0.158
C-G-T-T	58	0.123	C-G-T-T	29	0.141	C-G-T-T	25	0.091
T-A-T-C	41	0.087	T-A-T-C	11	0.053	T-A-T-C	23	0.084
T-G-T-T	23	0.049	T-G-T-T	6	0.029	T-G-T-T	19	0.069
C-A-T-T	4	0.008	C-A-T-T	1	0.005	C-A-T-T	3	0.011
C-G-T-C	3	0.006	C-G-T-C	2	0.010	C-G-T-C	2	0.007
C-G-G-C	2	0.004	C-A-G-C	2	0.010
T-A-T-T	1	0.002

The statistical analysis was performed by means of the exact test for sample differentiation based on haplotype frequencies. Alcoholic vs viral liver cirrhosis P < 0.05.