CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

Figure 2 Effects of CXCR4 antagonist on colonic myeloperoxidase (MPO), proinflammatory cytokines, and gut permeability in mice. Colitis was induced by administration of 5% DSS for 7 d. Colonic levels of tumor necrosis factor-α (TNF-α) (A), interleukin-6 (IL-6) (B), interferon-γ (IFN-γ) (C), MPO (D), and FD4 clearance (E) are shown. Eight mice were studied in each experimental group. Results are mean ± SE. ^aP < 0.05 vs control group; ^cP < 0.05 vs DSS + PBS group.