CXCR4 antagonist AMD3100 attenuates colonic damage in mice with experimental colitis

Figure 1 Effects of a chemokine stromal cell-derived factor-1 receptor (CXCR4) antagonist on mucosal damage in mice. Colitis was induced by administration of 5% dextran sulfate sodium (DSS) for 7 d. A: Common colonic morphologic characteristics are observed in tissue sections from control groups; B: Marked colonic injury is observed in tissue sections from the colitis group; C: Treatment with CXCR4 antagonist, AMD3100, significantly attenuates colonic damage; D: The histological score in mice. Eight mice were studied in each experimental group. Results are mean ± SE. ^aP < 0.05 vs control group; ^cP < 0.05 vs DSS + PBS group. Original magnification, × 200.