Hydrophobic protein in colorectal cancer in relation to tumor stages and grades

doi:10.3748/wjg.v16.i22.2754

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 14, 2010; 16(22): 2754-2763
Published online Jun 14, 2010. doi: 10.3748/wjg.v16.i22.2754

Table 2 Differentially expressed proteins in CRC

Protein spot	Protein name	SwissProt accession No.	Score	Theoretical molecular weight (Da)	Theoretical pI	Sequence coverage (%)	GRAVY	Fold change¹	TMR
S1	F1-ATPase β subunit	P06576	364	58 013	5.80	19	-0.030	+58.5	1
S2	Ubiquinol-cytochrome c reductase	P31930	171	53 308	5.94	7	-0.141	+32.8	1
S3	Calreticulin	P27797	73	47 092	4.30	11	-1.191	-31.9	1
S4¹^f	Tubulin α-1 chain	Q71U36	61	50 800	4.94	6	-0.229	+10.8	1
S5¹^c^f	Tubulin β-2 chain	P68371	299	48 142	4.70	25	-0.347	+20.8	1
S6	Chaperonin GroEL	P10809	185	61 348	5.70	8	-0.076	+265.0	3
S7	Heat shock 70 kDa protein	P11021	775	72 488	5.07	42	-0.487	+5.1	1
S8^a^b^c^d^e^f^g	Stomatin-like protein 2	Q9UJZ1	151	38 644	6.88	28	-0.161	+27.9	1
S9^a^e	Annexin A3	P12429	140	36 396	5.63	22	-0.430	+34.9	0
S10^a^b^c^e^f	Annexin A4	P09525	165	35 983	5.85	33	-0.447	+29.6	0
S11	Prohibitin	P35232	421	29 890	5.57	41	+0.024	+11.8	1
S12	Annexin A5	P08758	195	35 994	4.94	39	-0.330	-5.2	0
S13	ATP Synthase D chain	O75947	117	18 406	5.22	32	-0.569	+8.3	0

¹Fold change is given as the ratio of the spot intensity in normal mucosa over tumour tissue (negative variation or decrease) or tumor tissue over normal tissue (positive variation or increase).

^aDifferentially expressed proteins that are statistically significant (P < 0.05) among all 18 patients;

^bDifferentially expressed proteins that are statistically significant (P < 0.05) in Duke’s B stage;

^cDifferentially expressed proteins that are statistically significant (P < 0.05) in Duke’s C stage;

^dDifferentially expressed proteins that are statistically significant (P < 0.05) in WDC;

^eDifferentially expressed proteins that are statistically significant (P < 0.05) in MDC;

^fDifferentially expressed proteins that are statistically significant (P < 0.05) in female patients;

^gDifferentially expressed proteins that are statistically significant (P < 0.05) in male patients. pI: Isoelectric point; GRAVY: Grand average of hydrophobicity; TMR: Transmembrane region.

Citation: Yeoh LC, Loh CK, Gooi BH, Singh M, Gam LH. Hydrophobic protein in colorectal cancer in relation to tumor stages and grades. World J Gastroenterol 2010; 16(22): 2754-2763
URL: https://www.wjgnet.com/1007-9327/full/v16/i22/2754.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i22.2754