Treatment of iron deficiency anemia associated with gastrointestinal tract diseases

Table 4 Clinical studies comparing parenteral and oral iron therapy

Author	Intervention	Study method	n	Efficacy	P
Schröder et al[33]	Elemental iron 100-200 mg/d × 6 wk	Randomized	24	1RR: 53%	0.85
	Iron sucrose 7 mg/kg × one dose then 200 mg once-twice/wk × 5 wk		22	1RR: 55%
Erichsen et al[34]	Elemental iron 120 mg/d × 14 d	Crossover trial with a washout period of > 6 wk	17	Mean increase in Hb: 0.2	< 0.05
	Iron sucrose 200 mg on days 1, 5, 10		17	Mean increase in Hb: 0.7
Kulnigg et al[28]	Elemental iron 200 mg/d × 12 wk	2:1 (FeCarb:oral) randomization	136	Median increase in Hb: 2.8	NS
	FeCarb 1000 mg (max) weekly (× 1-3 wk)		60	Median increase in Hb: 3.7
Gisbert et al[35]	Elemental iron 106 mg/d × 3-6 mo	Hb ≥ 10.0 g/dL	78	2RR: 89%	NS
	Iron sucrose 200 mg twice/wk × 3-6 mo	Hb < 10.0 g/dL	22	2RR: 77%
Lindgren et al[36]	Elemental iron 200 mg/d × 20 wk	Randomized	46	1RR: 47%	0.07
	Iron sucrose 200 mg weekly until calculated dose reached		45	1RR: 66%

¹Increase in Hb ≥ 2.0 g/dL;

²Complete normalization of Hb. RR: Response rate.