Lifestyle-related disease in Crohn’s disease: Relapse prevention by a semi-vegetarian diet

Table 6 Maintenance therapy in Crohn's disease following induction of remission or response

	Induction therapy		Maintenance therapy
	Subjects	Regimen	Regimen	Duration
				1 yr	2 yr
Candy et al[55], 1995	CDAI > 200	PS (diminishing dose) + AZA 12 wk	AZA 2.5 mg/kg	Remission rate 42% (14/33)
			Placebo	7% (2/30)
Hanauer et al[56], 2002	CDAI ≥ 220	Gr (1) and Gr (2)	Gr (1) INFX 5 mg/kg every 8 wk	Remission rate 25% (28/113)
	Responder to a single infusion of infliximab	INFX 5 mg/kg at weeks 0, 2, 6	Gr (2) INFX 10 mg/kg every 8 wk	33% (37/112)
		Gr (3) INFX 5 mg/kg then placebo infusion at weeks 2, 6	Gr (3) placebo infusion every 8 wk	11% (12/110)
Sandborn et al[58], 2005	Mild to moderate CD	Budesonide 6 mg or 3 mg	Budesonide 6 mg or 3 mg	Relapse rate 60%-70%
			Placebo	(In all 3 groups)
Takagi et al[39], 2006	Active CD	TPN (25 cases), TEN (22 cases),	ED (half) + a free diet (half)	Relapse rate 26.9% (7/26)
		PS (1 case), INFX (3 cases)	A free diet	64.0% (16/25)
Regueiro et al[59], 2009	CD patients who had surgery	Ileocolonic resection	INFX 5 mg/kg at weeks 0, 2, 6	Remission rate 80% (8/10)
			then every 8 wk
			Placebo	58% (7/13)
Present study	Active CD	INFX 5 mg/kg at weeks 0, 2, 6 (16 cases), intestinal resection (5 cases), SSZ (1 case)	Semi-vegetarian diet	Remission rate 100% (16/16)	92%
			Omnivorous diet	67% (4/6)	25%

PS: Prednisolone; AZA: Azathioprine; CD: Crohn's disease; TPN: Total parenteral hypernutrition; TEN: Total enteral nutrition; ED: Elemental diet.