Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection

doi:10.3748/wjg.v16.i18.2265

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May 14, 2010 (publication date) through Apr 27, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 14, 2010; 16(18): 2265-2271
Published online May 14, 2010. doi: 10.3748/wjg.v16.i18.2265

Table 1 Comparison of baseline features among HBV, HCV, dual HBV and HCV, and non-HBV, non-HCV related hepatocellular carcinoma patients

	HBV n = 63	HCV n = 59	HBV + HCV n = 15	Non-HBV, non-HCV n = 28	P value
Age (yr)¹	55 (46-66)^a^c	66 (57-75)^a^d	60 (50-68)^d	61 (55-67)^c	< 0.001
Sex (M/F)	45/18	41/18	10/5	26/2	0.093
DM (%)	8 (12.7)^a	21 (35.6)^a^e	4 (26.7)	2 (7.1)^e	0.003
BMI (kg/m²)¹	24.3 (22.2-26.8)	23.8 (21.8-26.6)	23.6 (20.9-25.5)	24.5 (23.3-26.7)	0.439
Overweight (%)	24 (38)	22 (37)	4 (27)	10 (36)	0.797
Obesity (%)	4 (6)	5 (8)	1 (7)	2 (7)	0.965
AST (U/L)¹	48 (38-71)^a	72 (39-123)^a^e	72 (47-111)	38 (29-52)^e	0.002
ALT (U/L)¹	45 (34-63)^a	63 (29-100)^a^e	82 (54-117)	27 (21-39)^e	0.011
Child–Pugh class (A/B, C)	47/16	46/13	11/4	23/5	0.857
Platelet (10⁴/μL)¹	16.5 (12.0-25.0)^a	13.2 (8.7-17.1)^a^e	12.7 (7.6-18.1)^f	21.1 (15.3-24.1)^e^f	0.001
AFP (ng/mL)¹	15 (6-525)	28 (7-256)	38 (11-4388)	15 (6-8027)	0.468
Tumor size ( ≤ 3 cm) (%)	14 (22.2)^a	29 (49.2)^a^e	7 (46.7)	5 (17.9)^e	< 0.001
BCLC ( ≤ early stage) (%)	20 (31.7)^a^b	31 (52.5)^a^e^f	9 (60.0)^b	4 (14.3)^e^f	0.001
HOMA-IR	3.5 (2.0-8.6)^a	4.4 (2.9-6.6)^a	3.2 (1.7-10.7)	3.4 (2.0-4.6)	0.108
Insulin (μU/mL)¹	12.8 (8.4-25.0)	14.8 (9.9-21.30)	11.9 (8.1-23.5)	9.7 (7.6-14.8)	0.256
Adiponectin (μg/mL)	4.7 (2.9-8.1)^a^c	7.9 (5.2-11.0)^a^e	8.0 (3.8-10.9)^f	3.7 (2.0-6.0)^c^e^f	0.002

¹Median (interquartile range); P value by one-way ANOVA test or χ² test;

^aP < 0.05 between HBV and HCV;

^bP < 0.05 between HBV and HBV + HCV;

^cP < 0.05 between HBV and non-HBV, non-HCV;

^dP < 0.05 between HCV and HBV + HCV;

^eP < 0.05 between HCV and non-HBV, non-HCV;

^fP < 0.05 between HBV + HCV and non-HBV, non-HCV HCC with LSD post-hoc correction. HBV: Hepatitis B virus; HCV: Hepatitis C virus; DM: Diabetes mellitus; BMI: Body mass index; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; AFP: Alpha-fetoprotein; BCLC: Barcelona clinic liver cancer; HOMA-IR: Homeostasis model assessment of insulin resistance.

Citation: Hung CH, Wang JH, Hu TH, Chen CH, Chang KC, Yen YH, Kuo YH, Tsai MC, Lu SN, Lee CM. Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection. World J Gastroenterol 2010; 16(18): 2265-2271
URL: https://www.wjgnet.com/1007-9327/full/v16/i18/2265.htm
DOI: https://dx.doi.org/10.3748/wjg.v16.i18.2265