Apoptotic activity of caged xanthones from Garcinia hanburyi in cholangiocarcinoma cell lines

Table 5 Fold decrease or increase of apoptotic-related proteins of the four caged xanthone-treated compared to non treated CCA cell lines

Apoptotic proteins	Compounds	Fold change in protein of the treated cells compared to control cells
		KKU-100 (h)				KKU-M156 (h)
		0	12	24	48	0	12	24	48
Activated caspase-9	Isomorellinol	1	54	56	55	1	1	58	49
	Forbesione	1	9.6	13.1	13	1	5.7	8	5.6
	Gambogic acid	1	30	78	60	1	2.6	4.5	3.9
	Isomorellin	1	6.3	12.3	9.3	1	1	29	34
Activated caspase-3	Isomorellinol	1	10.6	11	11.2	1	20.2	30.4	33
	Forbesione	1	6	9.6	12	1	5.7	9.6	10
	Gambogic acid	1	5.5	7.5	12.2	1	28	39.3	46.7
	Isomorellin	1	8.9	10	13	1	5	5.7	12
Survivin	Isomorellinol	1	0.8	0.7	0.01	1	0.8	0.6	0.01
	Forbesione	1	0.5	0.54	0.3	1	0.7	0.54	0.5
	Gambogic acid	1	0.6	0.4	0.3	1	0.7	0.6	0.4
	Isomorellin	1	0.6	0.5	0.3	1	0.8	0.5	0.3
AIF	Isomorellinol	1	1.6	1.9	2.3	1	1.6	1.9	2.2
	Forbesione	1	1.2	1.6	2.1	1	1.6	2.8	4
	Gambogic acid	1	1.5	1.6	2.7	1	1.6	2.1	3.4
	Isomorellin	1	1.9	3.3	3.5	1	1.3	1.7	2.5

Data are expressed as ratio of mean of protein expression level of the apoptotic-related proteins in the caged xanthone-treated to non treated CCA cell lines.