Differentiation of focal liver lesions using three-dimensional ultrasonography: Retrospective and prospective studies

Table 3 Enhancement patterns using CE 3D US in three phases: positive predictive value in retrospective study

Enhancement patterns						Positive predictive value
No.	Early phase		Middle phase	Late phase	Enhancement changes	HCC	Metastasis	Hemangioma	FNH
	Tumor enhancement	Tumoral vessels	Tumor enhancement	Tumor echogenicity
1	Diffuse	Intratumoral	Diffuse	Hypoechoic	Washout	0.98 (81)	0.01 (1)	0.01 (1)	0.00 (0)
2	Diffuse	Intratumoral	Diffuse	Isoechoic	Persistence	0.60 (3)	0.00 (0)	0.40 (2)	0.00 (0)
3	Diffuse	Intratumoral	Peripheral ring-like	Hypoechoic	Washout	0.33 (2)	0.67 (4)	0.00 (0)	0.00 (0)
4	Diffuse	Intratumoral	Perfusion defect	Hypoechoic	Washout	0.67 (2)	0.33 (1)	0.00 (0)	0.00 (0)
5	Diffuse	Spoke-wheel arteries	Diffuse	Isoechoic	Persistence	0.00 (0)	0.00 (0)	0.00 (0)	1.00 (6)
6	Peripheral ring-like enhancement	Intratumoral	Diffuse	Isoechoic	Persistence	1.00 (3)	0.00 (0)	0.00 (0)	0.00 (0)
7	Peripheral ring-like enhancement	Intratumoral	Peripheral ring-like	Hypoechoic	Washout	0.14 (1)	0.86 (6)	0.00 (0)	0.00 (0)
8	Peripheral ring-like enhancement	Peritumoral	Peripheral ring-like	Hypoechoic	Washout	0.00 (0)	1.00 (12)	0.00 (0)	0.00 (0)
9	Peripheral ring-like enhancement	Peritumoral	Perfusion defect	Hypoechoic	Washout	0.00 (0)	1.00 (3)	0.00 (0)	0.00 (0)
10	Peripheral nodular	Peritumoral	Diffuse	Isoechoic	Persistence	0.00 (0)	0.00 (0)	1.00 (1)	0.00 (0)
11	Peripheral nodular	Peritumoral	Peripheral nodular	Hypoechoic	Persistence	0.00 (0)	0.00 (0)	0.67 (2)	0.00 (0)
12	Peripheral nodular	Peritumoral	Peripheral nodular	Isoechoic	Persistence	0.00 (0)	0.00 (0)	1.00 (1)	0.00 (0)
13	Peripheral nodular	Peritumoral	Peripheral nodular	Hypoechoic	Washout	0.00 (0)	0.33 (1)	0.00 (0)	0.00 (0)
14	Peripheral nodular	Absence	Diffuse	Isoechoic	Persistence	0.00 (0)	0.00 (0)	1.00 (2)	0.00 (0)
15	Peripheral nodular	Absence	Peripheral nodular	Hypoechoic	Persistence	0.00 (0)	0.00 (0)	1.00 (8)	0.00 (0)
16	Peripheral nodular	Absence	Peripheral nodular	Isoechoic	Persistence	0.00 (0)	0.00 (0)	1.00 (5)	0.00 (0)
17	Absence	Intratumoral	Diffuse	Isoechoic	Persistence	1.00 (3)	0.00 (0)	0.00 (0)	0.00 (0)
18	Absence	Intratumoral	Diffuse	Hypoechoic	Washout	1.00 (1)	0.00 (0)	0.00 (0)	0.00 (0)
19	Absence	Intratumoral	Peripheral ring-like	Hypoechoic	Washout	0.00 (0)	1.00 (1)	0.00 (0)	0.00 (0)
20	Absence	Intratumoral	Perfusion defect	Hypoechoic	Washout	1.00 (1)	0.00 (0)	0.00 (0)	0.00 (0)
21	Absence	Peritumoral	Peripheral ring-like	Hypoechoic	Washout	0.00 (0)	1 .00(1)	0.00 (0)	0.00 (0)
22	Absence	Peritumoral	Perfusion defect	Hypoechoic	Washout	0.00 (0)	1.00 (3)	0.00 (0)	0.00 (0)
23	Absence	Absence	Perfusion defect	Hypoechoic	Absence	0.33 (1)	0.67 (2)	0.00 (0)	0.00 (0)
24	Absence	Absence	Peripheral nodular	Hypoechoic	Persistence	0.00 (0)	0.00 (0)	1.00 (2)	0.00 (0)

Positive predictive values are presented with number of lesions in parentheses.