Application of hepatitis B virus replication mouse model

Figure 2 Evaluation of the effect of nucleoside analogues entecavir (ETV) and adefovir (ADV) on HBV replication using the HBV replication mouse model. After hydrodynamic transfection, mice were administered by oral gavage with two different nucleoside analogues: entecavir at a dose of 0.075 mg/kg per day and adefovir at a dose of 1.5 mg/kg per day for 3 d. A: HBV DNA replication intermediates in the mouse model treated with PBS (control), entecavir and adefovir, respectively; B: The relative levels of HBV DNA replication intermediates in the mouse model among different groups treated with PBS (control), entecavir and adefovir, respectively. The levels of HBV DNA replication intermediates in PBS treated group were set to 1, and the relative levels of treated groups were calculated accordingly.