Molecular determinants of the antitumor effects of trichostatin A in pancreatic cancer cells

Figure 4 SB202190 diminished inhibition of BrdU incorporation by TSA in BxPC-3 cells. The cells were treated with TSA, SB202190 and SB202474 at the indicated concentrations for 24 h, before DNA synthesis was assessed with the BrdU incorporation assay. 100% BrdU incorporation corresponds to untreated cells. Data are presented as mean ± SE (n = 16 separate cultures); ^aP < 0.05 vs control cultures, ^cP < 0.05 vs SB202474-treated cells (identical concentration of TSA) (Wilcoxon’s rank sum test).