Neoadjuvant chemoradiotherapy for esophageal cancer: Impact on extracapsular lymph node involvement

Table 4 Multivariate analysis of prognostic factors for patients with neoadjuvant CRT

Variable	HR	95% CI	P
Age	1.00	0.99-1.03	0.376
Sex			0.353
Male	1 (ref)
Female	0.77	0.44-1.34
pN/pM category			0.000
pN0/pM0	1 (ref)
pN1 (-)/pM0	1.89	1.10-3.22	0.021
pN1 (+)/pM0	2.70	1.57-4.64	0.000
pM1 lymph	2.92	1.49-5.74	0.002
pM1 organ	3.92	1.76-8.72	0.001
Histology			0.145
Squamous cell carcinoma	1 (ref)
Adenocarcinoma	0.73	0.48-1.11
Response			0.010
Minor response	1 (ref)
Major response	0.56	0.36-0.87

pN1 (-): pN1 category without extracapsular LNI; pN1 (+): pN1 category with extracapsular LNI.