Neoadjuvant chemoradiotherapy for esophageal cancer: Impact on extracapsular lymph node involvement

Table 2 Univariate survival analysis of 298 patients with advanced esophageal cancer

Variables	P	Surgery alone		Neoadjuvant CRT
		n	5-yr survival (%)	n	5-yr survival (%)
Patients	NS	108	20.4	190	25.6
Sex
Male	NS	86	22.0	151	24.4
Female	NS	22	13.8	39	32.6
Age (yr)
< 50	NS	11	58.3	38	33.7
50-70	0.015	65	15.8	124	24.7
> 70	NS	32	15.1	18	0.0
Histological subtype
Squamous cell carcinoma	NS	55	31.3	100	19.8
Adenocarcinoma	0.030	53	16.9	90	35.4
pN category
pN0	NS	27	36.5	98	41.6
pN1	NS	81	15.4	92	12.3
LN ratio
pN0	NS	27	36.5	98	41.6
LN ratio < 0.2	NS	52	23.7	69	10.3
LN ratio ≥ 0.2	NS	29	0.0	23	0.0
pM1 organ	NS	11	0.0	8	0.0
R category
R0	NS	98	22.1	179	26.4
R1/R2	NS	10	0.0	11	0.0
Response after neoadjuvant therapy
Minor response		-		112	11.4
Major response		-		78	42.4