Original Article
Copyright ©2010 Baishideng.
World J Gastroenterol. Apr 28, 2010; 16(16): 1953-1969
Published online Apr 28, 2010. doi: 10.3748/wjg.v16.i16.1953
Table 3 Binding capacity, cytotoxicity and antagonicity of HCV NS3 peptides
SequenceNamePeptide originPositionPeptide length (aa)IC50 (nmol/L)R2Cytotoxicity 10 nmol/L (%)1Inhibition1:1 (%)
CINGVCWTVWt1073HCV NS31073-1081954 6400.99486.74-
CINGVSWTVC1078SHCV NS3wt1073 (C6S)9 12710.99324.5759.30
YINGVCWTVC1073YHCV NS3wt1073 (C1Y)9 16270.99945.2144.70
CINGVCRTVW1079RHCV NS3wt1073 (W7R)9297 5000.99121.0254.50
YLVTRHADVWt1131HCV NS31131-11399  48000.99552.03-
YLVMRHADVT1134MHCV NS3wt1131 (T4M)9 72000.99144.5336.75
YLVTRYADVH1136YHCV NS3wt1131 (H6Y)9 74010.99335.5692.54
CLVTRHADVY1131CHCV NS3wt1131 (Y1C)9 83450.9952.0167.89
YLVTRRADVH1136RHCV NS3wt1131 (H6R)927 7000.99314.5347.46
LLCPAGHAVWt1169HCV NS31169-1177935 4400.99984.56-
LLCPAGHTVA1176THCV NS3wt1169 (A8T)927 6400.99827.7561.42
LLRPAGHAVC1171RHCV NS3wt1169 (C3R)982 1000.99759.9844.39
FLPSDFFPSVHBV-CoreHBV Core(18-27)[99]10481.10.999NSNS
SLYNTVATLHIV-p17HIV-1 p17(77-85)[100]9 42480.984NSNS
ILKEPVHGVHIV-RTHIV-1 Pol(476-484)[47]9 70820.997NSNS