Wilson disease: Histopathological correlations with treatment on follow-up liver biopsies

Table 2 Histopathology score of serial liver biopsies in WD patients who showed improved or stable hepatic fibrosis

Patient	Biopsy interval (yr)	Biopsy data			Iron staining	Treatment type
		Inflammation	Steatosis	Fibrosis
Group NP
11		0	0	0	None	-
	2	0	0	0	None	Zinc
21		0	2	0	None	-
	5	0	1	0	None	Zinc
3		2	1	2	None	-
	3	0	0	0	None	Zinc
	3	0	0	0	None	Zinc
4		0	1	1	3+, diffuse	-
	2	0	1	0	3+, diffuse	PCA
5		0	0	0	None	-
	4	0	0	0	None	PCA
6		0	2	0	Not done	-
	2	1	1	0	None	PCA
	4	1	1	0	2+, focal	PCA
Group P
7		0	2	0	None	-
	3	1	1	2	None	Zinc
8		1	1	0	Not done	-
	2	1	1	0	None	Zinc
	3	1	1	2	None	Zinc
	2	2	1	2	None	Zinc
9		0	3	1	1+, Kuppfer	-
	3	0	3	1	None	Zinc
	2	1	3	2	None	Zinc
	3	1	3	2	None	Zinc
10		1	0	2	None	Zinc
	12	2	1	3	None	PCA
11		0	0	0	2+	-
	5	1	0	2	None	PCA
12		0	0	1	None	-
	5	1	1	2	None	PCA

Grade of inflammation and steatosis are also described.

¹Indicates the two patients who presented with mixed hepatic and neurological phenotype. NP: Non-progressors; P: Progressors; Zinc: Zinc sulfate; PCA: Penicillamine.