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Copyright ©2010 Baishideng.
World J Gastroenterol. Mar 21, 2010; 16(11): 1349-1357
Published online Mar 21, 2010. doi: 10.3748/wjg.v16.i11.1349
Figure 2
Figure 2 Tumor necrosis factor (TNF) α and interferon (IFN) γ induce formation of immunoproteasome subunits. LMP7, LMP2 and MECL-1 subunits replace the constitutive catalytic subunits β5, β1 and β2, respectively, which shift the catalytic properties of the proteasome to generate MHC-I-binding peptides.