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Copyright ©2010 Baishideng.
World J Gastroenterol. Mar 21, 2010; 16(11): 1321-1329
Published online Mar 21, 2010. doi: 10.3748/wjg.v16.i11.1321
Figure 2
Figure 2 Role of the Toll-like receptor 4 (TLR4)-LPS signaling cascade in alcohol induced liver injury. LPS binds to LPS binding protein (LBP), transfers to cluster of differentiation 14 (CD14) and then to the TLR4 myeloid differentiation factor-2 (MD-2) complex. This signal is passed either through MyD88-dependent or TRIF-dependent intracellular pathways, which activate various transcription factors and induce various pro-inflammatory cytokine and Type I interferon genes.