Alcohol-induced alterations of the hepatocyte cytoskeleton

Table 2 Ethanol-induced changes in cytoskeletal protein expression levels

Protein	Expression levels	System	EtOH exposure	Ref.
α-tubulin	No change	WIF-B cells, rat liver, isolated hepatocytes	Chronic	[7,8]
α-tubulin	Decreased	Rat liver	Chronic	[9]
Dynein	No change	Rat liver	Chronic	[7]
Kinesin	No change	Rat liver	Chronic	[7]
Actin	No change	WIF-B cells, rat liver	Chronic	[10,11]
Cortactin	No change	WIF-B cells, Rat liver	Chronic	[11]
Vinculin	No change	Rat liver	Chronic	[10]
FAK	No change	Rat liver	Chronic	[10]
Paxillin	No change	Rat liver	Chronic	[10]
RhoA	No change	Rat liver	Chronic	[12]
Rac	Increased	Rat liver	Chronic	[12]
Cdc42	Increased	Rat liver	Chronic	[12]
α1 integrin	Increased	Rat liver	Chronic	[10,13]
α5 integrin	Increased	Rat liver	Chronic	[10,13]
β1 integrin	Increased	Rat liver	Chronic	[10,13]
Keratin 81	No change	Rat liver	Chronic	[14]
Keratin 181	No change	Rat liver	Chronic	[14]

¹Please see the text for a description of changes in keratins 8 and 18 protein expression levels that are associated with Mallory-Denk bodies in ethanol-fed human and mouse hepatocytes.