Influence of genes, sex, age and environment on the onset of autoimmune hepatitis

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Mar 7, 2009; 15(9): 1025-1034
Published online Mar 7, 2009. doi: 10.3748/wjg.15.1025

Table 1 Clinical and biochemical characteristics of type 1 and type 2 autoimmune hepatitis

	Characteristics
Type 1 AIH	Anti-SMA, anti-ANA and/or anti-SLA
	Mean age of onset: 10 yr old
	Female:Male ratio 3:1
	Higher incidence
	Frequently associated with IBD and sclerosing cholangitis
Type 2 AIH	Anti-LKM1 and/or anti-LC1
	Mean age of onset: 6.5 yr old
	Female:Male ratio 9:1
	Associated with HLA DR3, DR7 and DQB1*0201
	More severe disease
	More likely to be resistant to treatment

Citation: Béland K, Lapierre P, Alvarez F. Influence of genes, sex, age and environment on the onset of autoimmune hepatitis. World J Gastroenterol 2009; 15(9): 1025-1034
URL: https://www.wjgnet.com/1007-9327/full/v15/i9/1025.htm
DOI: https://dx.doi.org/10.3748/wjg.15.1025

Béland K, Lapierre P, Alvarez F. Influence of genes, sex, age and environment on the onset of autoimmune hepatitis. World J Gastroenterol 2009; 15(9): 1025-1034 [PMID: 19266593 DOI: 10.3748/wjg.15.1025]

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