Comparative study of omeprazole, lansoprazole, pantoprazole and esomeprazole for symptom relief in patients with reflux esophagitis

Figure 2 Daily changes in mean heartburn score for all subjects on each proton pump inhibitor regimen. (◆) Subjects administered omeprazole (n = 68), (■) Subjects administered lansoprazole (n = 69), (▲) Subjects administered pantoprazole (n = 69), (●) Subjects administered esomeprazole (n = 68). Significant difference between the omeprazole, lansoprazole, pantoprazole, and esomeprazole after 1 d drug administration (P = 0.0031, 0.0039, 0.0009, respectively). ○ significant difference between the omeprazole, lansoprazole, pantoprazole and esomeprazole after 2 d drug administration (P = 0.0092, 0.0088, 0.0036, respectively).