©2009 The WJG Press and Baishideng.
World J Gastroenterol. Feb 14, 2009; 15(6): 648-674
Published online Feb 14, 2009. doi: 10.3748/wjg.15.648
Published online Feb 14, 2009. doi: 10.3748/wjg.15.648
Table 11 Common causes of late dysfunction in the pediatric population
| Incidence at 5 yr (%) | Risk factors | |
| Acute rejection | Variable (< 30) | Inadequate immunosuppression |
| Treatment with immune activating drugs (e.g. interferon) | ||
| History of autoimmune liver disease | ||
| Chronic rejection | -3 | Inadequate immunosuppression |
| Treatment with immune-activating drugs (e.g. interferon) | ||
| Refractory acute rejection | ||
| Chronic rejection in a previous failed allograft | ||
| Recurrent AIH | -30 | Suboptimal immunosuppression |
| AIH type I | ||
| Severe inflammation in native liver | ||
| HLA DR3 or DR4 | ||
| De novo AIH | < 5 | |
| Recurrent PBC | 20-30 | Tacrolimus as baseline immunosuppression |
| Living-related donor | ||
| Steroid and other immunosuppression withdrawal | ||
| Recurrent PSC | 20-30 | Male sex; donor-recipient gender mismatch |
| Intact colon at time of transplantation | ||
| Idiopathic post-transplant hepatitis | 5-60 |
- Citation: Spada M, Riva S, Maggiore G, Cintorino D, Gridelli B. Pediatric liver transplantation. World J Gastroenterol 2009; 15(6): 648-674
- URL: https://www.wjgnet.com/1007-9327/full/v15/i6/648.htm
- DOI: https://dx.doi.org/10.3748/wjg.15.648