Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome

Table 3 Major water soluble metabolites contributing to differentiation between patients and controls¹

Metabolite	Fold (IBS/healthy control)	P value2	FDR Q value
2(3H)-furanone	13.7	0.03	0.25
Ribitol	3.6	NS	0.25
Heptan	2.9	0.02	0.25
L-Mannose	2.8	NS	0.25
Creatinine	1.7	0.04	0.25
Dodecane	1.5	NS	0.29
Decanoic acid	1.3	NS	0.52
Dodecanoic acid	-1.5	NS	0.25
n-Butylamine	-1.5	0.01	0.25
D-ribose	-1.5	NS	0.25
Glucopyranose	-1.6	NS	0.29
Azelaic acid	-1.8	0.02	0.25
Adipic acid	-2.7	0.0008	0.05

¹Separation is based on a variable importance projection (VIP) analysis with a cut-off value of 2;

²Wilcoxon rank sum test. NS: Not significant.